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Updated: Nov 11, 2025

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Psoriasis: Comorbidities.

Fumikazu Yamazaki1

  • 1Department of Dermatology, Kansai Medical University, Osaka, Japan.

The Journal of Dermatology
|March 25, 2021
PubMed
Summary
This summary is machine-generated.

Psoriasis is a systemic inflammatory disease linked to cardiovascular issues. This review examines psoriasis complications and the cardiac effects of biologic treatments.

Keywords:
complicationmajor adverse cardiovascular diseasemetabolic syndromepsoriasis

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Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis was historically linked to diet and obesity.
  • Psoriasis is now understood as a systemic inflammatory disease.
  • Cytokines in psoriasis can trigger other diseases, increasing risks for cardiovascular and cerebrovascular conditions.

Purpose of the Study:

  • To review objective data on psoriasis and its complications.
  • To explore the impact of biologic therapies on cardiovascular disease in psoriasis patients.

Main Methods:

  • Literature review of various reports and reviews.
  • Analysis of data on psoriasis complications.
  • Examination of biologic treatments' effects on cardiac vascular disease.

Main Results:

  • Psoriasis patients face higher incidences of cerebral and cardiovascular diseases.
  • Individuals with psoriasis experience a younger age at death compared to healthy individuals.
  • Current guidelines lack clarity on vascular lesion testing frequency for psoriasis patients.

Conclusions:

  • Psoriasis is a systemic inflammatory condition with significant cardiovascular implications.
  • Biologics, a primary psoriasis treatment, warrant further investigation for their impact on cardiac vascular health.
  • Further research is needed to establish clear guidelines for vascular monitoring in psoriasis management.