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Nanotechnology-Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

Özlem Şen1, Melis Emanet1,2, Gianni Ciofani1

  • 1Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, Pontedera, Pisa, 56025, Italy.

Advanced Healthcare Materials
|March 25, 2021
PubMed

Insights

Nanomaterials offer novel strategies for detecting and treating cancer metastasis, a major cause of cancer mortality. This review explores how nanostructures impact cancer cell spread and blood vessel formation within tumors.

Area of Science:

  • Oncology and Nanomedicine

Background:

  • Cancer metastasis is a primary driver of cancer morbidity and mortality.
  • Metastatic cells' ability to spread and tumor heterogeneity pose significant therapeutic challenges.
  • Nanomaterials offer unique properties for developing advanced cancer theranostics.

Purpose of the Study:

  • To review nanomaterial-based approaches for cancer metastasis detection and treatment.
  • To focus on the impact of nanostructures on key metastatic processes.
  • To evaluate nanostructure effects on cell migration, invasion, and angiogenesis.

Main Methods:

  • Review of current literature on nanomaterials in cancer metastasis.
  • Analysis of studies investigating nanostructure-tumor microenvironment interactions.
  • Focus on theranostic applications of nanomaterials.

Main Results:

  • Nanomaterials show potential for targeted delivery and imaging in metastasis.
  • Specific nanostructure characteristics influence cancer cell migration and invasion.
  • Nanomaterials can modulate angiogenesis within the tumor microenvironment.

Conclusions:

  • Nanomaterial-based strategies are promising for combating cancer metastasis.
  • Understanding nanostructure-cell interactions is crucial for therapeutic development.
  • Further research can optimize nanomaterials for enhanced anti-metastatic therapies.
Keywords:
angiogenesiscancerinvasionmetastasisnanomaterials

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