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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

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A comprehensive review on oncogenic miRNAs in breast cancer

Maryam Maryam1, Mahsa Naemi, Shahrzad Sheikh Hasani

  • 1Department of Fetomaternal, Faculty of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran 14155-6559, Iran. Shahrzad.SheikhHasani@gmail.com.

Journal of Genetics
|March 25, 2021
PubMed

Insights

Oncogenic microRNAs (miRNAs) drive breast cancer progression by affecting cell migration, apoptosis, proliferation, and angiogenesis. This review explores miRNA-based therapies, including mimics and inhibitors, for targeted breast cancer treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Oncogenic microRNAs (miRNAs) play a critical role in breast cancer (BC) progression.
  • These miRNAs influence key hallmarks of cancer, including cell migration, invasion, metastasis, apoptosis inhibition, cell proliferation, and angiogenesis.
  • Understanding the specific roles of oncogenic miRNAs offers potential for novel targeted BC therapies.

Purpose of the Study:

  • To review the key oncogenic miRNAs implicated in breast cancer progression.
  • To discuss miRNA-based therapeutic strategies for targeted breast cancer treatment.
  • To summarize evidence for the clinical potential of miRNA-based therapies in breast cancer.

Main Methods:

  • Comprehensive literature review of oncogenic miRNAs in breast cancer.
  • Analysis of miRNAs involved in cell migration, invasion, metastasis, apoptosis, proliferation, and angiogenesis.
  • Examination of various miRNA-based therapeutic approaches, including mimics, inhibitors, sponges, nanoparticles, and artificial miRNAs.

Main Results:

  • Identified key oncogenic miRNAs (e.g., miR-9, miR-21, miR-155, miR-17/92) involved in multiple BC processes.
  • Detailed various miRNA-based therapeutic modalities such as miRNA mimics, anti-miRNA oligonucleotides (AMOs), miRNA sponges, and nanoparticles.
  • Highlighted the potential of these therapeutic strategies for clinical application in breast cancer treatment.

Conclusions:

  • Oncogenic miRNAs are crucial drivers of breast cancer and represent promising therapeutic targets.
  • miRNA-based therapies, including mimics and inhibition strategies, offer novel avenues for targeted BC treatment.
  • Further research and clinical translation of these miRNA-based approaches are warranted for effective breast cancer management.

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