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Aging and Chronic Liver Disease

Raquel Maeso-Díaz1, Jordi Gracia-Sancho2,3

  • 1Division of Gastroenterology, Department of Medicine, Duke University Health System, Durham, North Carolina.

Seminars in Liver Disease
|March 25, 2021
PubMed

Insights

Aging significantly impacts chronic liver disease (CLD) by altering liver sinusoidal cells. Targeting aging pathways offers a novel therapeutic strategy for liver diseases and extending healthspan.

Area of Science:

  • Hepatology and Aging Research

Background:

  • Aging is the primary risk factor for chronic liver disease (CLD) incidence and severity.
  • The hepatic sinusoid, crucial for liver function, comprises hepatocytes, liver sinusoidal endothelial cells, hepatic stellate cells, and macrophages.
  • Age-related changes in hepatic sinusoidal cells and their impact on CLD are not fully understood.

Purpose of the Study:

  • To review age-related alterations in the hepatic sinusoid.
  • To discuss the implications of these changes for CLD development and treatment.
  • To propose aging as a therapeutic target for liver diseases.

Main Methods:

  • Literature review of studies on aging, hepatic sinusoid, and chronic liver disease.
  • Analysis of experimental models investigating age-related changes in liver cells.
  • Synthesis of current knowledge on therapeutic strategies.

Main Results:

  • Aging induces significant phenotypic and functional changes in all hepatic sinusoidal cell types.
  • These age-related alterations contribute to CLD development and progression.
  • Existing studies in aging and liver disease models show consistent alterations across sinusoidal cells.

Conclusions:

  • Age-related changes in the hepatic sinusoid are critical factors in CLD.
  • Targeting the aging process presents a promising therapeutic avenue for liver diseases.
  • Interventions aimed at aging may improve CLD outcomes and promote healthspan.

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