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Updated: Nov 11, 2025

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Evaluation of cardiomyopathy diagnosis in heart transplant recipients: comparison of echocardiographic and pathologic

Neda Behzadnia1, Babak Sharif-Kashani2, Zargham Hossein Ahmadi1

  • 1Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology
|March 25, 2021
PubMed

Insights

Echocardiography and pathology results for cardiomyopathy diagnosis often differ before heart transplantation. This study found significant discrepancies, highlighting the need for advanced imaging or biopsy for accurate pre-transplant assessment.

Area of Science:

  • Cardiology
  • Pathology
  • Medical Imaging

Background:

  • Diagnosing cardiomyopathy types can be difficult in end-stage disease.
  • Inconsistencies between echocardiography and pathology in cardiomyopathy classification are increasingly reported.
  • Pre-heart transplant diagnosis may not align with post-transplant pathological findings.

Purpose of the Study:

  • To compare pre-heart transplant echocardiographic diagnoses of cardiomyopathy with post-transplant pathological findings.
  • To evaluate the diagnostic accuracy of echocardiography for cardiomyopathy classification before heart transplantation.

Main Methods:

  • Retrospective cross-sectional clinicopathological study.
  • Analysis of 100 consecutive heart transplant patients (2010-2019).
  • Comparison of echocardiographic diagnosis with post-transplant pathological results.

Main Results:

  • A significant difference (P < 0.001) was observed in cardiomyopathy type frequency between echocardiography and pathology.
  • In 24% of patients, echocardiographic findings were inconsistent with pathological results.
  • Mean patient age was 40 ± 13 years, with 79% males.

Conclusions:

  • Significant discrepancies exist between echocardiographic and pathological diagnoses of cardiomyopathy.
  • Additional diagnostic tools, such as advanced cardiac imaging or endomyocardial biopsy, are recommended before heart transplantation.
  • Accurate pre-transplant diagnosis is crucial for developing appropriate treatment strategies.
Abstract

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