Bi-direction effects between microbiome and MiRNAs in carcinogenesis.

Area of Science:

• Microbiology
• Molecular Biology
• Oncology

Background:

• Gut microbiome dysbiosis is associated with immune-mediated diseases, obesity, diabetes, and cancer.
• The precise regulatory network governing host-gut microbiome communication remains incompletely defined.
• MicroRNAs (miRNAs) are increasingly recognized as key mediators in host-microbiome interactions.

Purpose of the Study:

• To summarize the bidirectional effects between miRNAs and the microbiome.
• To elucidate the role of miRNA-microbiome interactions in carcinogenesis.
• To highlight the potential of understanding this association for cancer treatment and diagnosis.

Main Methods:

• Literature review of studies on miRNA-microbiome interactions.
• Analysis of mechanisms regulating host-gut communication.
• Synthesis of evidence regarding miRNA involvement in cancer development.

Main Results:

• miRNAs play a crucial role in mediating communication between the host and the gut microbiome.
• Dysbiosis influences various diseases, including cancer, through metabolite and genetic regulation.
• The interplay between miRNAs and the microbiome significantly impacts carcinogenesis.

Conclusions:

• Understanding the miRNA-host-microbiome axis is vital for advancing cancer remission, diagnosis, and treatment.
• miRNA-microbiome interactions may serve as potential biomarkers for cancer.
• Further research into this bidirectional communication could lead to novel therapeutic strategies.