Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

304
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
304
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

707
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
707
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

423
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
423

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-reported experience in device-assisted enteroscopy: Conscious sedation vs. general anesthesia.

Endoscopy international open·2026
Same author

Completion Small Bowel Capsule Endoscopy after Device-assisted Enteroscopy in Management of Patients with Small Bowel Disease.

Endoscopy international open·2026
Same author

Capsule Endoscopy for Treat-to-Target Monitoring in Crohn's Disease: A Systematic Review and Meta-Analysis.

Gastrointestinal endoscopy·2026
Same author

Right biopsy protocol for microscopic colitis: Reduced workload and carbon footprint while maintaining diagnostic accuracy.

World journal of gastrointestinal pharmacology and therapeutics·2026
Same author

The investigation and treatment of Helicobacter pylori for the prevention of gastric cancer: A narrative review and assessment of management approaches.

Digestive diseases (Basel, Switzerland)·2026
Same author

Safety of argon plasma coagulation for small bowel angiodysplasia during balloon-assisted enteroscopy in patients on antithrombotic therapy: a single-centre observational cohort study.

Scandinavian journal of gastroenterology·2026

Related Experiment Video

Updated: Nov 11, 2025

Author Spotlight: Detection and Treatment of Helicobacter pylori Infection
06:40

Author Spotlight: Detection and Treatment of Helicobacter pylori Infection

Published on: July 28, 2023

4.0K

Endoscopic Detection of Helicobacter pylori by the Rapid Urease Test.

Vikrant Parihar1, Deirdre McNamara2,3

  • 1Department of Gastroenterology, Trinity Academic Gastroenterology Group Research Centre, Trinity Centre, Tallaght University Hospital, Dublin 24, Ireland.

Methods in Molecular Biology (Clifton, N.J.)
|March 25, 2021
PubMed
Summary

Detecting Helicobacter pylori infection via endoscopic biopsy is improved by taking additional proximal specimens. Optimizing biopsy protocols enhances diagnostic accuracy for H. pylori testing.

Keywords:
Diagnostic yieldEndoscopyHelicobacter pyloriHistologyRapid urease test

More Related Videos

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology
03:33

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology

Published on: May 23, 2025

425
Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology
05:13

Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology

Published on: June 13, 2025

427

Related Experiment Videos

Last Updated: Nov 11, 2025

Author Spotlight: Detection and Treatment of Helicobacter pylori Infection
06:40

Author Spotlight: Detection and Treatment of Helicobacter pylori Infection

Published on: July 28, 2023

4.0K
Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology
03:33

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology

Published on: May 23, 2025

425
Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology
05:13

Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology

Published on: June 13, 2025

427

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Diagnostic Medicine

Background:

  • Helicobacter pylori infection is a common cause of gastric diseases.
  • Endoscopic biopsy is a primary method for detecting H. pylori.
  • Standard biopsy protocols may be limited by sampling error and infection prevalence.

Purpose of the Study:

  • To evaluate the impact of biopsy location on the diagnostic accuracy of H. pylori detection.
  • To assess the effectiveness of enhanced biopsy protocols in improving H. pylori test sensitivity.
  • To highlight the need for wider adoption of optimized biopsy techniques.

Main Methods:

  • Analysis of diagnostic yield from endoscopic biopsy specimens.
  • Comparison of H. pylori detection rates using standard versus extended biopsy protocols.
  • Review of factors influencing diagnostic accuracy, including sampling error and prior treatment.

Main Results:

  • Additional proximal biopsy specimens significantly increase the sensitivity of invasive H. pylori tests.
  • Optimized biopsy protocols are recommended, particularly in patients treated with proton-pump inhibitors.
  • Despite improved yield, combined Rapid Urease Tests (RUTs) are not widely adopted.

Conclusions:

  • Enhanced biopsy protocols, including additional proximal specimens, are crucial for improving H. pylori detection rates.
  • Standardization and adoption of appropriate biopsy protocols are essential to minimize sampling error and enhance diagnostic yield.
  • Further efforts are needed to promote the use of evidence-based biopsy strategies in clinical practice.