Fecal Microbiota Transplantation beyond Clostridioides Difficile Infection

Area of Science:

• Microbiology
• Gastroenterology
• Immunology

Background:

• Advancing analytical methods reveal gut microbes' role in gastrointestinal and non-gastrointestinal diseases.
• Gut dysbiosis is implicated in numerous pathological conditions.
• Research is actively exploring microbial modulation for disease prevention and treatment.

Purpose of the Study:

• To review the role of gut microbes in disease pathogenesis.
• To highlight the therapeutic potential of fecal microbiota transplantation (FMT).
• To discuss current and future applications of FMT in clinical practice.

Main Methods:

• Review of current scientific literature on gut microbiota and FMT.
• Analysis of studies investigating FMT in various disease models.
• Synthesis of evidence regarding FMT efficacy and safety.

Main Results:

• Gut microbes are associated with a wide range of diseases.
• Fecal microbiota transplantation (FMT) is effective for Clostridioides difficile infection.
• FMT shows potential applications in inflammatory bowel disease, irritable bowel syndrome, NAFLD, metabolic syndrome, obesity, and diabetes.

Conclusions:

• Fecal microbiota transplantation (FMT) is a promising therapeutic strategy.
• Further research and evidence accumulation are needed for broader clinical application.
• FMT may offer treatment options for currently intractable diseases.