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Updated: Nov 11, 2025

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Higher frailty burden in older adults with chronic constipation
Jihye Lim1, Hyungchul Park2, Heayon Lee3
1Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, Republic of Korea.
Chronic constipation (CC) is linked to frailty in older adults. This geriatric syndrome requires clinical attention in frail individuals.
Area of Science:
- Geriatrics
- Gastroenterology
- Epidemiology
Background:
- Constipation is common in older adults, but its link to frailty is understudied.
- Investigating the association between chronic constipation (CC) and frailty is crucial for geriatric care.
Purpose of the Study:
- To examine the relationship between chronic constipation (CC) and frailty in community-dwelling older adults.
Main Methods:
- Cross-sectional analysis of 1278 older adults using Rome criteria for CC (IBS-C, FC).
- Frailty assessed via Cardiovascular Health Study (CHS) frailty phenotype.
- Logistic regression analyzed associations adjusted for age, sex, and multimorbidity.
Main Results:
- 10.7% of participants had CC; they were older with worse physical performance.
- Chronic constipation (CC) prevalence was significantly associated with frailty (P < .001).
- CHS frailty score independently predicted CC presence in multivariate analysis.
Conclusions:
- Frailty is significantly associated with chronic constipation (CC) in older adults.
- Constipation should be recognized as a geriatric syndrome in frail elderly patients.
- Clinical practice should consider CC in the management of frail older individuals.
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