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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Diagnostic capability of different morphological parameters for primary open-angle glaucoma in the Chinese population
Ruoshi Li1, Xia Wang1, Yahui Wei1
1Department of Ophthalmology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi Cheng District, 100034, Beijing, People's Republic of China.
BMC Ophthalmology
|March 26, 2021
Summary
The Bruch
Area of Science:
- Ophthalmology and visual sciences.
- Glaucoma diagnostics.
- Ophthalmic imaging analysis.
Background:
- Assessing novel Bruch's membrane opening (BMO)-based disc parameters for glaucoma diagnosis.
- Comparing BMO-minimum rim width (BMO-MRW) and BMO-minimum rim area (BMO-MRA) against established metrics.
- Evaluating diagnostic capabilities in the Chinese population.
Purpose of the Study:
- To evaluate the diagnostic performance of BMO-MRW and BMO-MRA.
- To compare these novel parameters with retinal nerve fiber layer (RNFL) from optical coherence tomography (OCT) and rim area (RA) from Heidelberg retinal tomograph-III (HRT-III).
- To determine their utility in diagnosing primary open-angle glaucoma (POAG).
Main Methods:
- Cross-sectional study including 200 eyes (77 healthy, 123 POAG).
- Utilized visual field testing, OCT, and HRT-III for structural measurements.
- Calculated Areas Under the Receiver Operating Characteristic Curves (AUCs) to assess diagnostic power.
Main Results:
- BMO-MRW and BMO-MRA demonstrated superior diagnostic power compared to RA.
- Global BMO-MRW showed comparable AUCs to RNFL in discriminating POAG from controls.
- BMO-MRA and BMO-MRW showed comparable diagnostic power to RNFL in myopic and macrodisc populations.
Conclusions:
- BMO-MRW exhibits diagnostic power comparable to RNFL.
- BMO-MRA may offer advantages in specific populations like those with macrodiscs.
- All OCT-derived parameters outperformed RA in diagnostic capability.
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