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Enzyme changes after coronary angiography.

A Weikl, M Hubmann, O E Durst

    Cardiovascular Radiology
    |July 25, 1978
    PubMed
    Summary
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    Coronary angiography using contrast media did not significantly elevate most cardiac enzymes, except for a transient increase in gamma-glutamyl transferase. High creatine phosphokinase levels were linked to thymus carcinoma, not the procedure.

    Area of Science:

    • Cardiology
    • Clinical Enzymology
    • Radiology

    Background:

    • Contrast media are frequently used in coronary angiography.
    • Potential enzymatic alterations following contrast media administration require investigation.

    Purpose of the Study:

    • To evaluate the enzymatic response to contrast media after coronary angiography.
    • To assess the impact of contrast media on specific cardiac and liver enzymes.

    Main Methods:

    • Enzyme levels (SGOT, SGPT, LDH, alpha-HBDH, gamma-GT, CPK, CK-MB) were measured in 24 patients post-coronary angiography.
    • In vitro studies examined contrast media effects on gamma-GT, LDH, and CPK activities.

    Main Results:

    • No significant elevations in SGOT, SGPT, alpha-HBDH, LDH, or CK-MB were observed.

    Related Experiment Videos

  • Gamma-glutamyl transferase (gamma-GT) showed a transient increase up to 12 hours post-procedure.
  • Elevated CPK and CK-MB in one patient were attributed to thymus carcinoma, not angiography.

    • Conclusions:

    • Coronary angiography with contrast media does not significantly affect most measured cardiac enzymes.
    • Contrast media concentrations do not inhibit key enzymes (gamma-GT, LDH, CPK) in vitro.
    • Transient gamma-GT elevation is a notable finding, while other enzyme changes may indicate underlying pathology.