Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comprehensive transcriptomic analysis in wild-type and ATM knockout lung cancer cells: Influence of cisplatin on oxidative stress-induced senescence.

Chemico-biological interactions·2025

Same author

Inhibition of MSH6 augments the antineoplastic efficacy of cisplatin in non-small cell lung cancer as autophagy modulator.

Chemico-biological interactions·2024

Same author

Enhancing cisplatin drug sensitivity through PARP3 inhibition: The influence on PDGF and G-coupled signal pathways in cancer.

Chemico-biological interactions·2024

Same author

Glycosylated nanoplatforms: From glycosylation strategies to implications and opportunities for cancer theranostics.

Journal of controlled release : official journal of the Controlled Release Society·2024

Same author

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements.

Biomolecules·2019

Same author

A combination of left ventricular hypertrabeculation/noncompaction and muscular dystrophy in a stroke patient.

International journal of cardiology·2014

Search research articles

Related Experiment Video

Updated: Nov 11, 2025

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

Multi-omics approaches to improve malaria therapy.

Min Zhou¹, Ayşegül Varol¹, Thomas Efferth¹

¹Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.

Pharmacological Research

|March 26, 2021

Summary

This summary is machine-generated.

Multi-omics technologies offer a holistic view of malaria parasite biology, aiding the development of new drugs and vaccines. Continued research is crucial to overcome drug resistance and improve malaria treatment outcomes.

Keywords:

Drug development Drug resistance Infectious diseases Plasmodium Treatment targets Vaccine Vector-borne disease

More Related Videos

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

Published on: November 10, 2015

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Related Experiment Videos

Last Updated: Nov 11, 2025

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

Published on: November 10, 2015

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Area of Science:

Infectious Diseases
Genomics
Proteomics
Metabolomics

Background:

Malaria remains a major global health challenge, exacerbated by increasing drug resistance in Plasmodium parasites.
Current antimalarial therapies face significant hurdles due to evolving parasite resistance mechanisms.
There is a critical need for novel therapeutic strategies to combat malaria effectively.

Purpose of the Study:

To review the application of multi-omics technologies in malaria research.
To highlight advances in multi-omics approaches for understanding malaria parasite biology.
To discuss drug resistance mechanisms and explore novel therapeutic and vaccine developments.

Main Methods:

Review of multi-omics technologies (genomics, transcriptomics, proteomics, metabolomics) applied to malaria.
Analysis of recent research integrating diverse omics data.
Examination of molecular mechanisms underlying antimalarial drug resistance.

Main Results:

Multi-omics approaches provide a comprehensive understanding of malaria parasite functional dynamics.
Significant progress has been made in identifying resistance mechanisms and potential drug targets.
Novel drug and vaccine candidates are emerging from omics-driven research.

Conclusions:

Multi-omics technologies are instrumental in advancing malaria control efforts.
Bridging the gap between basic research and clinical application is essential for translating findings into patient benefit.
Further research is needed to fully exploit multi-omics potential for developing next-generation antimalarials and vaccines.