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Adaptive perfusion: An in vitro release test (IVRT) for complex drug products

Deval Patel1, Ying Zhang2, Yixuan Dong3

  • 1Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA; Office of Quality Surveillance, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 26, 2021
PubMed
Summary

A novel adaptive perfusion method, a type of tangential flow filtration (TFF), accurately measures drug release rates from complex drug products. This advanced technique offers faster and more comprehensive drug release analysis compared to traditional methods.

Keywords:
Adaptive perfusionDrug releaseGlobule sizeNanoemulsionsTangential flow filtration

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