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Increased plasma malondialdehyde in patients with small intestinal strangulation obstruction
T A Otamiri1, C Tagesson, R Sjödahl
1Department of Surgery, University Hospital, Linköping, Sweden.
Acta Chirurgica Scandinavica
|April 1, 1988
Summary
Plasma malondialdehyde (MDA) indicates lipid peroxidation in small intestinal obstruction. Elevated MDA levels in strangulation obstruction suggest its diagnostic utility.
Area of Science:
- Biochemistry
- Surgical Pathology
Background:
- Intestinal obstruction is a common surgical emergency.
- Lipid peroxidation is a marker of cellular damage.
Purpose of the Study:
- To evaluate plasma malondialdehyde (MDA) as a diagnostic index for small intestinal obstruction, differentiating between simple and strangulated cases.
Main Methods:
- Plasma MDA levels were measured in 20 patients with small intestinal obstruction (9 strangulated, 11 simple) and 29 healthy controls.
- MDA concentrations were compared across groups using statistical analysis.
Main Results:
- Mean MDA levels were significantly higher in strangulation obstruction (6.7 ± 1.6 μmol/l) compared to simple obstruction (2.9 ± 0.5 μmol/l) and controls (2.3 ± 0.7 μmol/l).
- All strangulation cases exhibited MDA levels above 4 μmol/l, while simple obstruction cases had lower values.
Conclusions:
- Elevated plasma MDA levels are indicative of intestinal strangulation.
- MDA can serve as a valuable diagnostic biomarker for identifying strangulation in small intestinal obstruction.