Related Experiment Video
Updated: Nov 11, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
Published on: August 25, 2023
Proteogenomics drives therapeutic hypothesis generation for precision oncology
1Lester and Sue Smith Breast Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA.
Proteogenomics, combining genomic and proteomic analyses, offers deeper insights into tumors than single analyses. This approach promises better patient matching to targeted cancer treatments.
Area of Science:
- Oncology
- Genomics
- Proteomics
Background:
- Precision oncology relies heavily on genomic profiling.
- Current genomic approaches have shown limited success in improving patient outcomes.
Purpose of the Study:
- To explore the potential of proteogenomics in cancer research.
- To investigate if combining genomic and proteomic data provides superior insights compared to individual analyses.
Main Methods:
- Integrating genomic and proteomic data from tumors.
- Comparative analysis of single 'omic' data versus combined proteogenomic data.
Main Results:
- Proteogenomics provides deeper mechanistic insights into tumor biology.
- Combined analyses generate more robust therapeutic hypotheses.
Conclusions:
- Proteogenomics offers a promising strategy to enhance precision oncology.
- This integrated approach can improve patient stratification for targeted therapies.
More Related Videos
03:08Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
10:27Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Related Concept Videos
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Microorganisms in Medicine and Therapeutics
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Genomics