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Daratumumab: The perplexity in immunohematology with emerging horizons in myeloma therapy

Soma Agrawal1, Mohit Chowdhry1, Prashant Karna1

  • 1Department of Transfusion Medicine and Transplant Immunology, Indraprastha Apollo Hospital, New Delhi, India.

Asian Journal of Transfusion Science
|March 26, 2021
PubMed

CD38 is a disulfide-linked molecule present on red blood cells (RBCs) and daratumumab; an anti-CD38 monoclonal antibody is a novel agent for treating multiple myeloma patients. It also binds to the RBC along with the plasma cells in concern, creating a menace in the immunohematology workups and requires the use of dithiothreitol-treated cells to rule out its interference. Appropriate and timely communication with the clinicians about the patient history goes a long way in solving complex looking immunohematology workups.

Keywords:
Anti-CD38daratumumabimmunohematologymultiple myeloma

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