Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

820
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
820

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electric Breakdown of Dielectric Polymers is Strongly Correlated to Mechanical Toughness.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

A successful individualized comprehensive therapy for carbapenem-resistant Klebsiella pneumoniae induced multifocal brain abscesses: a case report and literature review.

BMC infectious diseases·2026
Same author

Evaluating the ecological effects of daily hydropeaking on lithophilous fish spawning habitat in a large mountainous river.

Journal of environmental management·2026
Same author

Killing Two Birds With One Stone: Electrochemical Nitrate Reduction to Ammonia at the Cathode Coupled With High Value-Added Chemical Production at the Anode.

Small methods·2025
Same author

Fern-Leaf-Inspired Multifunctional Flexible Strain Sensors for Motion Monitoring, Information Communication and Health Alert.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

"Tear-And-Stack" Twisted SrTiO<sub>3</sub> Moiré Superlattices for Precise Interfacial Reconstruction and Polar Topology.

Advanced materials (Deerfield Beach, Fla.)·2025

Related Experiment Video

Updated: Nov 11, 2025

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

8.2K

Current Immunotherapies for Glioblastoma Multiforme.

Boyuan Huang1, Xuesong Li2, Yuntao Li3

  • 1Department of Neurosurgery, Beijing Electric Power Hospital, Beijing, China.

Frontiers in Immunology
|March 26, 2021
PubMed
Summary

Glioblastoma multiforme (GBM) treatments face challenges with low efficacy. Immunotherapy offers promising avenues, requiring combined approaches for improved outcomes in brain tumor treatment.

Keywords:
checkpoint inhibitorsglioblastoma multiformegliomaimmunotherapyvaccines

More Related Videos

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

21.7K
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

27.6K

Related Experiment Videos

Last Updated: Nov 11, 2025

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

8.2K
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

21.7K
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

27.6K

Area of Science:

  • Neuro-oncology
  • Immunology
  • Cancer Therapy

Background:

  • Glioblastoma multiforme (GBM) is an aggressive central nervous system malignancy.
  • Current treatments (surgery, radiation, chemotherapy) have limited therapeutic efficiency and poor prognosis.
  • Immunotherapy strategies show promise in preclinical and clinical settings.

Purpose of the Study:

  • To review the current landscape of glioblastoma multiforme treatment.
  • To highlight the potential of various immunotherapy approaches for GBM.
  • To propose future directions for integrated GBM immune therapy.

Main Methods:

  • Review of existing literature on glioblastoma multiforme treatments.
  • Analysis of preclinical and clinical trial data for immunotherapy in GBM.
  • Synthesis of information on vaccine therapy, cell therapy, and other immunomodulatory strategies.

Main Results:

  • Standard GBM treatments exhibit limited efficacy.
  • Immunotherapy approaches including peptide vaccines, dendritic cell vaccines, CAR T-cells, checkpoint inhibitors, and oncolytic virotherapy show promising results.
  • The tumor microenvironment presents a significant challenge.

Conclusions:

  • Future glioblastoma multiforme treatment necessitates integrated immunotherapy strategies.
  • Rational combinations of vaccine, cell, radio-, and chemotherapy are crucial.
  • Targeting the tumor microenvironment is essential for enhancing therapeutic efficacy.