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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: Nov 11, 2025

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Omics analyses in keratoconus: from transcriptomics to proteomics.

Jingwen Cai¹, Amy Estes^2,3, Yutao Liu^1,3,4

¹Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912.

Current Ophthalmology Reports

|March 26, 2021

Summary

This summary is machine-generated.

Recent transcriptomics and proteomics studies reveal key genes and proteins involved in keratoconus (KC) pathogenesis, particularly those related to extracellular matrix and TGFβ signaling, advancing our understanding of this corneal disease.

Keywords:

Cornea Genetics Keratoconus Proteomics Transcriptomics

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Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

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Published on: September 11, 2023

Area of Science:

Ophthalmology
Genomics
Proteomics

Background:

Keratoconus (KC) is a progressive corneal ectasia.
Understanding its molecular basis is crucial for developing effective treatments.

Purpose of the Study:

To review advances in transcriptomics and proteomics for keratoconus research.
To highlight genome-wide gene and protein expression profiling techniques.

Main Methods:

RNA sequencing for genome-wide gene expression analysis in KC tissues/cells.
Mass spectrometry for high-throughput proteomics studies.

Main Results:

Differential gene expression identified in KC, implicating extracellular matrix, WNT-signaling, TGFβ pathway, and NRF2 network.
Proteomics revealed KC-related proteins in cytoskeleton, cell matrix, TGFβ signaling, and ECM remodeling pathways.
Gene and protein expression findings are largely consistent.

Conclusions:

Transcriptomics and proteomics identify significant genes/proteins contributing to keratoconus pathogenesis.
Extracellular matrix and TGFβ signaling pathways are implicated.
Future studies require larger sample sizes and standardized methodologies.