A Clinical Nomogram for Predicting Lymph Node Metastasis in Penile Cancer: A SEER-Based Study
Wei Zhang1, Pan Gao1, Jingjing Gao1
1Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Frontiers in Oncology
|March 26, 2021
Summary
A new nomogram helps predict lymph node metastasis in penile squamous cell carcinoma (SCCP) patients. This tool uses clinicopathological factors to aid in counseling and treatment decisions for SCCP.
Area of Science:
- Oncology
- Urology
- Medical Statistics
Background:
- Penile squamous cell carcinoma (SCCP) is a rare malignancy.
- Lymph node metastasis is a critical prognostic factor in SCCP.
- Accurate prediction of metastasis is essential for treatment planning.
Purpose of the Study:
- To develop and validate a predictive nomogram for lymph node metastasis in SCCP patients.
- To identify significant clinicopathological predictors of lymph node involvement.
Main Methods:
- Retrospective analysis of 1,016 SCCP patients from the SEER database (2004-2015).
- Logistic regression for univariate and multivariate analyses to identify predictors.
- Nomogram construction and validation using calibration plots and ROC analysis.
Main Results:
- 19% of patients (195/1016) had lymph node metastasis.
- Age, primary tumor site, grade, tumor size, and T stage were significant predictors (p < 0.05).
- The nomogram demonstrated good discrimination (c-index = 0.776) and calibration.
Conclusions:
- The developed nomogram effectively predicts lymph node metastasis risk in SCCP.
- This tool can assist in patient counseling and guide clinical treatment decisions.
- The nomogram integrates key clinicopathological factors for risk stratification.
