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The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia

Soudeh Ghafouri-Fard1, Atefe Abak2, Mahdi Mohaqiq3,4

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Cell and Developmental Biology
|March 26, 2021
PubMed

Insights

Insulin-like growth factors (IGFs) regulate cell growth and are implicated in diseases. Non-coding RNAs interact with IGF signaling, influencing disease development and potential therapeutic responses.

Area of Science:

  • Molecular Biology
  • Genetics
  • Endocrinology

Background:

  • Insulin-like growth factors (IGFs) are crucial polypeptides regulating cell growth, development, maturation, and aging.
  • IGF signaling pathways, including MAPK, Akt, and PI3K, are implicated in various diseases such as neoplasia, insulin resistance, and diabetes mellitus.
  • Emerging research highlights the significant interplay between non-coding RNAs and IGF signaling in disease pathogenesis.

Purpose of the Study:

  • To review and synthesize current data on the role of non-coding RNAs associated with IGF signaling in the development of neoplasia and other related conditions.
  • To understand how non-coding RNAs modulate IGF pathways in the context of various diseases.
  • To establish the necessity of identifying the impact of non-coding RNAs for predicting therapeutic responses to IGF-targeting strategies.

Main Methods:

  • Literature review and data synthesis.
  • Analysis of existing research on IGF signaling and non-coding RNAs.
  • Exploration of the functional roles of non-coding RNAs in IGF pathway modulation.

Main Results:

  • Non-coding RNAs play fundamental roles in the development of IGF-associated disorders.
  • The interplay between non-coding RNAs and IGF signaling is critical in the pathogenesis of diseases like cancer and metabolic disorders.
  • Specific non-coding RNAs can significantly influence IGF pathway activity.

Conclusions:

  • Non-coding RNAs are key regulators in IGF signaling pathways.
  • Understanding the role of non-coding RNAs in IGF signaling is essential for developing targeted therapies.
  • Identification of non-coding RNA involvement can aid in predicting patient response to novel therapeutic strategies for IGF-related conditions.
Keywords:
IGFdisordersexpressionlncRNAmiRNA

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