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Updated: Nov 11, 2025

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
Published on: December 21, 2016
Mechanistic and Translational Advances Using iPSC-Derived Blood Cells
Christopher S Thom1, Stella T Chou2, Deborah L French3
1Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Abstract:
Human induced pluripotent stem cell (iPSC)-based model systems can be used to produce blood cells for the study of both hematologic and non-hematologic disorders. This commentary discusses recent advances that have utilized iPSC-derived red blood cells, megakaryocytes, myeloid cells, and lymphoid cells to model hematopoietic disorders. In addition, we review recent studies that have defined how microglial cells differentiated from iPSC-derived monocytes impact neurodegenerative disease. Related translational insights highlight the utility of iPSC models for studying pathologic anemia, bleeding, thrombosis, autoimmunity, immunodeficiency, blood cancers, and neurodegenerative disease such as Alzheimer's.
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