Honey and its protein components: Effects in the cancer immunology

The immune system plays an important role in cancer development, but some tumor cells can evade or inhibit the processes of innate and adaptive immunity. This review made a description of honey and its proteins effect on diverse mediators from the immune system. Scientific evidence reported that many types of honey (jungle, manuka, pasture, and others) and some isolated proteins enhanced the release of reactive oxygen species (O₂^- and H₂ O₂ ) and cytokines (mostly IL-1β, IL-6, and TNF-α) by innate immune system cells. Furthermore, honey elicited proliferation and functions of T lymphocytes, cells related to specific adaptive immune responses. These studies have established a precedent over the honey and its properties on the immune system, demonstrating that it can promote the innate and adaptive immunity. PRACTICAL APPLICATIONS: Cancer is a genetic illness that represents a world health problem. Recognizing the potential of diet therapy in the prevention and treatment of chronic diseases, the present work summarizes the effects of honey on the immune system and mediators involved in cancer elimination processes, establishing the importance of this natural product as a future anticancer agent.