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Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
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Association between myocardial work and functional capacity in patients with arterial hypertension: an

Marijana Tadic1, Cesare Cuspidi2,3, Biljana Pencic1

  • 1Department of Cardiology, University Hospital 'Dr. Dragisa Misovic - Dedinje', Belgrade, Serbia.

Blood Pressure
|March 26, 2021
PubMed

Insights

Myocardial performance declines with poorly controlled hypertension. Global myocardial work is linked to functional capacity, even in patients with uncontrolled or resistant hypertension.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Hypertension significantly impacts cardiovascular health.
  • Assessing myocardial performance is crucial for understanding hypertensive heart disease.

Purpose of the Study:

  • To evaluate myocardial performance using pressure-strain loops in hypertensive patients.
  • To analyze myocardial performance across different blood pressure control levels.

Main Methods:

  • Cross-sectional study of 204 subjects including controls and hypertensive patients.
  • Utilized two-dimensional echocardiography and speckle-tracking echocardiography.
  • Calculated global myocardial work, constructive work, wasted work, and work efficiency via pressure-strain curves.

Main Results:

  • Left ventricular longitudinal strain decreased progressively with worsening hypertension control.
  • Global myocardial work was elevated in uncontrolled and resistant hypertension groups compared to controls.
  • Global myocardial work index correlated with peak oxygen consumption, independent of other clinical factors.

Conclusions:

  • Uncontrolled and resistant hypertension significantly impair myocardial work compared to well-controlled hypertension and controls.
  • Global myocardial work is an independent predictor of functional capacity in hypertensive individuals.
Abstract

Keywords:
Hypertensionleft ventriclemyocardial work

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