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Beating a skullduggerous infantile hemispheric high-grade glioma
Ashwin Kumaria1, Matthew A Kirkman1, Simon P Howarth1
1Department of Neurosurgery, Queen's Medical Centre, Nottingham, UK.
British Journal of Neurosurgery
|March 26, 2021
Summary
A rare infantile hemispheric high-grade glioma was successfully treated in a five-month-old boy. He is now three years old with only minor developmental delays, showing positive outcomes from surgical and oncological interventions.
Area of Science:
- Pediatric neuro-oncology
- Neurosurgery
- Developmental pediatrics
Background:
- High-grade gliomas are aggressive brain tumors with poor prognoses, particularly in infants.
- Infantile hemispheric gliomas present unique challenges due to early-onset and location.
Observation:
- A five-month-old male infant presented with concerning 'beaten copper pot' skull imaging.
- The infant was diagnosed with an infantile hemispheric high-grade glioma.
Findings:
- A comprehensive surgical and oncological treatment plan was implemented.
- The patient demonstrated a positive response to treatment, remaining well at a three-year follow-up.
Implications:
- Early diagnosis and aggressive multimodal treatment can lead to favorable outcomes in infantile hemispheric high-grade gliomas.
- Long-term surveillance is crucial to monitor for tumor recurrence and manage developmental sequelae.
- This case highlights the potential for successful management of rare pediatric brain tumors.