Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

207
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
207
Cardiopulmonary Resuscitation I: Adult01:21

Cardiopulmonary Resuscitation I: Adult

273
Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
273
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

75
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
75
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

94
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
94
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

112
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
112
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

1.0K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Central nervous system penetration of imatinib in acute lymphoblastic leukemia: Pharmacokinetic analysis and clinical implications.

Cancer chemotherapy and pharmacology·2026
Same author

Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial.

JAMA·2026
Same author

Postresuscitation Cerebral Vasospasm and Capillary Failure After Experimental Asphyxial Cardiac Arrest.

Journal of the American Heart Association·2026
Same author

The contribution of growth to the SDA response in pythons.

The Journal of experimental biology·2026
Same author

Characteristics and Short-Term Outcomes of Patients With Acute Pulmonary Embolism Requiring Intubation.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2026
Same author

Bone strength parameters of the femoral shaft and the influence of age, BMI and vBMD: Implications for forensic fracture evaluation.

Forensic science international·2026

Related Experiment Video

Updated: Nov 11, 2025

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography
08:21

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Published on: October 11, 2022

2.3K

Optimizing hemodynamic function during cardiopulmonary resuscitation.

Lauge Vammen1,2, Jesper Fjølner1,3, Kasper Hansen2,4,5,6

  • 1Department of Intensive Care, Aarhus University Hospital.

Current Opinion in Critical Care
|March 26, 2021
PubMed
Summary

Emerging therapies like head-up cardiopulmonary resuscitation (CPR) and aortic occlusion aim to optimize blood flow during cardiac arrest. These advanced techniques show promise for improving cerebral perfusion, though further clinical testing is needed.

More Related Videos

Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

12.8K
Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

8.0K

Related Experiment Videos

Last Updated: Nov 11, 2025

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography
08:21

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Published on: October 11, 2022

2.3K
Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

12.8K
Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

8.0K

Area of Science:

  • Cardiology
  • Emergency Medicine
  • Physiology

Background:

  • Chest compressions during cardiopulmonary resuscitation (CPR) exhibit significant inter-individual anatomical variations.
  • Advanced imaging reveals compression primarily targets atria and right ventricle, not the left ventricle.

Purpose of the Study:

  • To review current understanding of hemodynamics during CPR.
  • To describe novel therapies for optimizing perfusion during CPR.

Main Methods:

  • Review of cadaver studies using advanced CT techniques.
  • Analysis of animal studies and clinical trials on head-up CPR.
  • Examination of studies on resuscitative endovascular balloon occlusion of the aorta (REBOA) during CPR.

Main Results:

  • Hemodynamic-directed CPR strategies may allow for individualized interventions.
  • Head-up CPR demonstrates potential for improving cerebral perfusion in preliminary studies.
  • REBOA can be safely implemented during ongoing CPR in initial investigations.

Conclusions:

  • Modern imaging enhances understanding of CPR mechanisms and perfusion optimization.
  • Head-up CPR and REBOA are promising novel techniques to improve cerebral perfusion during CPR.
  • Both head-up CPR and REBOA require further clinical validation.