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Comparative nanometallomics as a new tool for nanosafety evaluation
Liming Wang1,2, Jiating Zhao1,2, Liwei Cui2
1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety; CAS-HKU Joint Laboratory of Metallomics on Health and Environment; Beijing Metallomics Facility; National Consortium for Excellence in Metallomics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
This review expands nanometallomics to include all nanomaterials, not just metallic ones. A new approach, comparative nanometallomics, uses machine learning for precise and high-throughput nanosafety evaluation.
Area of Science:
- Environmental Science
- Toxicology
- Materials Science
Background:
- Nanosafety evaluation is crucial for human health, environmental protection, and regulatory frameworks.
- Current nanometallomics primarily focuses on metallic nanomaterials, neglecting non-metallic counterparts.
- A comprehensive approach is needed to assess the safety of diverse nanomaterials.
Purpose of the Study:
- To critically review and expand the concept of nanometallomics to encompass all types of nanomaterials.
- To highlight the importance of studying the impact of nanomaterials on metal(loid), biomolecular, and elemental homeostasis.
- To introduce comparative nanometallomics as an advanced tool for robust nanosafety assessment.
Main Methods:
- Critical review of existing nanometallomics literature.
- Conceptual expansion of nanometallomics to include non-metallic nanomaterials.
- Proposal of comparative nanometallomics, leveraging machine learning for high-throughput analysis.
Main Results:
- Nanometallomics is redefined to include the study of impacts from all nanomaterials on biological systems.
- The homeostasis of metal(loid)s, biomolecules, and elements is identified as a key focus area.
- Comparative nanometallomics offers a precise and efficient method for nanosafety evaluation.
Conclusions:
- The expanded definition of nanometallomics is essential for a holistic understanding of nanomaterial safety.
- Comparative nanometallomics represents a significant advancement in high-throughput nanosafety assessment.
- Future research directions include metallo-wide association studies and non-target nanometallomics.
