Related Experiment Video

Updated: Nov 11, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

127

MicroRNA: A signature for cancer progression

Bashdar Mahmud Hussen1, Hazha Jamal Hidayat2, Abbas Salihi3

  • 1Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 26, 2021
PubMed

Insights

MicroRNAs (miRNAs) are small RNAs crucial in gene regulation and cancer development. Profiling these molecules aids in cancer detection, staging, and understanding oncogenic pathways.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • Aberrant miRNA expression is implicated in the initiation, progression, and metastasis of human cancers.
  • Changes in miRNA quantity and quality are key factors in cancer development.

Purpose of the Study:

  • To discuss circulating miRNA signatures and their expression profiles in various cancers.
  • To explore the impact of miRNAs on cellular processes relevant to oncogenesis.
  • To highlight the role of miRNA profiling in cancer detection, staging, and therapy response.

Main Methods:

  • Review of scientific literature on miRNA expression profiling in human cancers.
  • Analysis of studies correlating miRNA signatures with cancer characteristics.
  • Discussion of mechanisms underlying miRNA dysregulation in cancer (e.g., epigenetic factors, transcriptional regulation).

Main Results:

  • Circulating miRNA signatures show promise as biomarkers for cancer detection and staging.
  • Altered miRNA expression impacts oncogenic pathways and cellular processes.
  • Specific miRNA profiles correlate with cancer progression and response to treatment.

Conclusions:

  • miRNA expression profiling is a valuable tool in oncology.
  • Understanding miRNA alterations provides insights into cancer pathogenesis.
  • Circulating miRNAs hold potential for non-invasive cancer diagnostics and prognostics.
Keywords:
CancerExpressionMiRNA

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