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Updated: Nov 11, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

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When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a

Marie-Léa Gauci1,2,3, Barouyr Baroudjian3, Celeste Lebbe4,2,3

  • 1U976, INSERM, Paris, Île-de-France, France marie-lea.gauci@aphp.fr.

Journal for Immunotherapy of Cancer
|March 27, 2021
PubMed

Immune-related hepatitis (IRH) is a frequent but poorly understood immune-related adverse event and its frequency increases since the use of combination therapy in several cancer types. Therefore, there is an urgent need to develop adapted guidelines to manage IRH.In the present letter, based on Ziogas et al report entitled 'When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report', several points are discussed: assessment of IRH severity and liver biopsy indication, immune-related cholangitis as a differential diagnosis for some IRH presentation, the need of steroids for IRH management or the indication for second line immunosuppressive treatment and finally, the possibility of immunotherapy resumption.

Keywords:
immunotherapymelanoma

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