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Regulation of Stroke Volume

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...

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Updated: Nov 11, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

Regulatory T cells in ischemic stroke.

Hong-Yun Wang¹, Jun-Rui Ye¹, Li-Yuan Cui¹

¹State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Acta Pharmacologica Sinica

|March 27, 2021

Summary

This summary is machine-generated.

Regulatory T (Treg) cells play a complex role in ischemic stroke (IS) pathology. This review explores their dual function in immune response modulation and potential as a therapeutic target for stroke recovery.

Keywords:

crosstalk inflammation ischemic stroke ischemic stroke therapy regulatory T cells stroke-induced immunodepression

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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

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Published on: January 3, 2025

Area of Science:

Neuroimmunology
Stroke Pathophysiology

Background:

Ischemic stroke (IS) involves blood-brain barrier (BBB) disruption and immune cell infiltration.
Regulatory T (Treg) cells are crucial for immune homeostasis and suppressing immune responses.
The precise role of Treg cells in IS outcomes remains debated, with varying effects across disease stages.

Purpose of the Study:

To elucidate the modulatory role of Treg cells in IS-induced immune responses.
To review Treg cell dynamics and functions in both central nervous system (CNS) and peripheral tissues after IS.
To explore Treg cell involvement in post-stroke inflammation and immunodepression.

Main Methods:

Review of experimental animal and human studies on Treg cell behavior post-IS.
Analysis of Treg cell biological functions and mechanisms.
Discussion of Treg cell participation in inflammatory and immunosuppressive processes following stroke.

Main Results:

Treg cells exhibit dynamic fluctuations in response to IS.
Their functions vary significantly depending on the IS stage and location (CNS vs. periphery).
Treg cells influence both post-stroke inflammation and systemic immunosuppression.

Conclusions:

Treg cells have a complex, stage-dependent impact on IS.
Understanding Treg cell mechanisms is vital for stroke management.
Treg cells represent a promising therapeutic avenue for IS treatment.