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Updated: Nov 11, 2025
12:17
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
Published on: May 21, 2017
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Differences in life expectancy between men and women after aortic valve replacement
Daniel Hernandez-Vaquero1, Emiliano Rodriguez-Caulo2, Carlota Vigil-Escalera1
1Cardiac Surgery Department, Central University Hospital of Asturias, Oviedo, Spain.
Summary
Aortic valve replacement does not restore life expectancy in patients aged 50-65. Women face a higher long-term mortality risk after this procedure compared to men.
Area of Science:
- Cardiology
- Thoracic Surgery
- Public Health
Background:
- Severe aortic stenosis necessitates aortic valve replacement (AVR) in patients aged 50-65.
- Previous studies suggest AVR may not fully restore life expectancy in younger patients.
- Sex-based differences in long-term outcomes post-AVR require further investigation.
Purpose of the Study:
- To confirm if AVR restores life expectancy in patients aged 50-65.
- To investigate potential sex-based differences in survival after AVR.
- To determine if female sex is an independent risk factor for mortality post-AVR.
Main Methods:
- Retrospective analysis of 50-65 year old patients undergoing isolated AVR across 27 Spanish centers over 18 years.
- Comparison of observed survival with expected survival at 10 and 15 years.
- Competing risks analysis to estimate cumulative incidence of death.
- Stratification by sex to identify independent risk factors for mortality.
Main Results:
- At 15 years, observed survival for men was 72.3% vs. expected 78.8%; for women, observed was 73% vs. expected 89.4%.
- Cumulative incidence of death at 15 years was 8.2% for men and 16.7% for women.
- Female sex was identified as an independent risk factor for death (HR=1.23, P=0.03).
Conclusions:
- AVR does not fully restore life expectancy in patients aged 50-65.
- Women experience a significantly greater loss of life expectancy post-AVR compared to men.
- Female sex is an independent predictor of long-term mortality following aortic valve replacement, warranting further research into underlying causes.
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