Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

898
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
898
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

796
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
796

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seizure outcomes after laser interstitial thermal therapy for pediatric extratemporal lobe epilepsy.

Journal of neurosurgery. Pediatrics·2026
Same author

Stereo-EEG mapping of visual working memory with task-related high-gamma modulations.

Epilepsia·2026
Same author

Diaphragm dysfunction following congenital heart surgery: Epidemiology and outcomes.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Optimal hematoma volume cutoffs and efficacy of minimally invasive surgery for thalamic hemorrhage: a propensity score-matched analysis.

BMC neurology·2026
Same author

Complications of Pancreatitis-Knowledge Gaps and Research Opportunities: A Workshop Summary.

Pancreas·2026
Same author

Monkeypox virus: Pandemic and antiviral drugs.

Microbial pathogenesis·2026

Related Experiment Video

Updated: Nov 11, 2025

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.8K

Epilepsy phenotypes associated with MAP1B-related brain malformations.

Ravindra Arya1, Christine Spaeth2, Wenying Zhang3

  • 1Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Epileptic Disorders : International Epilepsy Journal with Videotape
|March 27, 2021
PubMed
Summary

Loss-of-function variants in the MAP1B gene are linked to periventricular heterotopia (PVH) and seizures. This study identifies a novel MAP1B variant, expanding the known clinical and neuroimaging spectrum for this genetic condition.

Keywords:
genetic epilepsyperisylvian polymicrogyriaperiventricular heterotopia

More Related Videos

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.1K
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.3K

Related Experiment Videos

Last Updated: Nov 11, 2025

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.8K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.1K
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.3K

Area of Science:

  • Genetics
  • Neurology
  • Neuroscience

Background:

  • Whole-exome sequencing (WES) studies suggest MAP1B gene variants are associated with periventricular heterotopia (PVH).
  • The neurological phenotypes linked to MAP1B variants remain incompletely understood.

Purpose of the Study:

  • To characterize the clinical and neuroimaging features of individuals with PVH and potential MAP1B gene variants.
  • To identify novel genetic variants associated with PVH and related neurological symptoms.

Main Methods:

  • Integrated genomic analysis, including whole-exome sequencing (WES) and microarray, was performed on four family members.
  • Clinical evaluations included assessment of seizure types, developmental milestones, behavioral observations, and neuroimaging.

Main Results:

  • Affected family members presented with diverse seizures (febrile, fever-triggered, afebrile), photosensitivity, mild developmental delays, obsessive-compulsive behaviors, and attention deficits.
  • Neuroimaging revealed periventricular heterotopia (PVH), corpus callosum abnormalities, and perisylvian polymicrogyria.
  • A novel heterozygous frameshift variant in the MAP1B gene was identified in all affected individuals.

Conclusions:

  • This study expands the known clinical and neuroimaging spectrum associated with pathogenic MAP1B variants.
  • MAP1B variants should be considered in patients presenting with febrile and afebrile seizures, especially when accompanied by characteristic neuroimaging findings like PVH.