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The apoprotein pattern in normolipemic peripheral vascular disease.
E Mannarino1, D Siepi, L Pistola
12nd Department of Internal Medicine, University of Perugia, Italy.
Angiology
|June 1, 1988
Summary
Peripheral vascular disease (PVD) patients showed higher triglycerides and lower HDL-cholesterol. Plasma apoprotein levels were similar, but the triglyceride/Apo-E ratio was elevated in PVD.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
Background:
- Peripheral vascular disease (PVD) is a condition affecting blood circulation.
- The link between PVD and plasma apoproteins requires further elucidation.
Purpose of the Study:
- To investigate the lipid and apoprotein profiles in normolipemic patients with PVD.
- To compare these profiles with those of healthy normolipemic individuals.
Main Methods:
- A comparative study involving 20 normolipemic PVD patients and 20 healthy normolipemic controls.
- Analysis of plasma lipid levels, including triglycerides and HDL-cholesterol.
- Quantification of various plasma apoproteins (AI, AII, B, CII, CIII, E).
Main Results:
- PVD patients exhibited significantly higher mean triglyceride levels (107.8 mg% vs 73.3 mg%) and lower mean HDL-cholesterol (36.5 mg% vs 44.4 mg%) compared to controls.
- No significant differences were found in the mean plasma levels of apoproteins AI, AII, B, CII, CIII, and E between the groups.
- The mean triglyceride/Apo-E ratio was significantly higher in PVD patients (52.3 vs 23.3).
Conclusions:
- Normolipemic PVD is associated with dyslipidemia, characterized by elevated triglycerides and reduced HDL-cholesterol.
- Specific plasma apoprotein levels do not appear to differ significantly between PVD patients and healthy individuals.
- The elevated triglyceride/Apo-E ratio may serve as a potential indicator in PVD, warranting further investigation.