Related Experiment Video

Updated: Nov 11, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K

COVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis

Paulo Roberto Gabbai-Armelin1, Analú Barros de Oliveira1, Túlio Morandin Ferrisse1

  • 1School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.

European Journal of Clinical Investigation
|March 27, 2021
PubMed

Insights

Older patients with COVID-19 (coronavirus disease 2019) who have hypertension, diabetes, and elevated D-dimer levels face a higher risk of thrombotic events.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Epidemiology

Background:

  • COVID-19 (coronavirus disease 2019) is linked to serious hematological issues, particularly thrombotic events.
  • Thrombotic complications are a significant concern in patients with SARS-CoV-2 infection.

Purpose of the Study:

  • To systematically review the literature on the relationship between COVID-19 and thrombotic events.
  • To identify key prognostic factors associated with these thrombotic events in COVID-19 patients.

Main Methods:

  • A systematic literature search was conducted across PubMed, Web of Science, and Scopus.
  • Qualitative analysis used Oxford level of evidence and Newcastle-Ottawa scale; meta-analysis assessed prognostic factors like age and D-dimer levels.
  • Publication bias was evaluated using funnel plots and trim-and-fill tests.

Main Results:

  • Twenty articles underwent qualitative analysis; six were included in the meta-analysis.
  • Hypertension and diabetes were frequently associated comorbidities with thrombotic events.
  • Elevated D-dimer levels (P < .0001) and older age (P = .0202) were significant prognostic factors for thrombotic events in COVID-19 patients.

Conclusions:

  • Age over 60 years is a prognostic factor for thrombotic events in COVID-19.
  • Comorbidities such as hypertension and diabetes increase the risk.
  • D-dimer levels exceeding 3.17 µg/mL are indicative of a higher risk for thrombotic events in COVID-19 patients.
Abstract

Keywords:
COVID-19D-dimerSARS-CoV-2meta-analysisprognostic factorssystematic reviewthrombosis

More Related Videos

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

872
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.3K

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
106
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
107
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
109
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
102
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.2K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
206