Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vaccination Against Serogroup B Meningococcal Disease: Current Status and Future Perspectives-A Consensus Document of the World Association for Infectious Diseases and Immunological Disorders (WAidid).

Vaccines·2026

Same author

Uncertainty-Aware, End-to-End Deep Learning for Functional Lung MRI Quantification Using <sup>129</sup>Xe and <sup>1</sup>H MRI.

Radiology. Cardiothoracic imaging·2026

Same author

Identifiability and Model Misspecification for Modelling Recurrent Infections Using Routine Health Care Data.

American journal of epidemiology·2026

Same author

Longitudinal <sup>1</sup>H and <sup>129</sup>Xe Lung MRI in Patients With Post-COVID Residual Lung Abnormalities.

Journal of magnetic resonance imaging : JMRI·2026

Same author

Maternal preferences for infant respiratory syncytial virus (RSV) preventives: an Australian discrete choice experiment.

Vaccine·2026

Same author

Impact of grassroots development of interprofessional team-based practices: Retrospective matched cohort study using ICES data.

Canadian family physician Medecin de famille canadien·2026

Same journal

The Ameliorative Effect of Spirulina platensis as Add-On Therapy to Risperidone on Valproic Acid-Induced Autism in Rat Pups: Implication of Oxidative Stress, Inflammatory, and ERK-1/2 Signaling Pathway.

Developmental neurobiology·2026

Same journal

From Behavioral and Sleep Disturbances to Genetic Diagnosis: Smith-Magenis Syndrome and the Importance of the Diagnostic Pathway.

Developmental neurobiology·2026

Same journal

Is There Any Difference in the Novel Serum Inflammatory Biomarkers of Adolescents With DMDD and Bipolar Disorder?

Developmental neurobiology·2026

Same journal

An Effective LRSF-DLNN-Based Autism Spectrum Disorder Prediction Using EEG and fMRI.

Developmental neurobiology·2026

Same journal

Disrupted Vestibular Nuclei Neuron Development in a Chick Model for Congenital Vestibular Disorders.

Developmental neurobiology·2026

Same journal

Association Analysis Between HEI-2020 Index and Maternal Pregnancy Behaviors on ADHD in Adolescent Populations: A NHANES Cross-Sectional Study.

Developmental neurobiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 11, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

Using organoids to study human brain development and evolution.

Wai-Kit Chan¹, Rana Fetit¹, Rosie Griffiths¹

¹Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK.

Developmental Neurobiology

|March 27, 2021

Summary

This summary is machine-generated.

Cerebral organoids offer a novel way to study human brain development and disease, overcoming limitations of animal models. Understanding their current limitations is key to maximizing their potential in neuroscience research.

Keywords:

cerebral organoids human cortical development human cortical evolution human embryonic neurodevelopment

More Related Videos

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Published on: March 24, 2023

Related Experiment Videos

Last Updated: Nov 11, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Published on: March 24, 2023

Area of Science:

Neuroscience
Developmental Biology
Biotechnology

Background:

Cerebral organoids provide a human-based model for studying brain development and disease.
Traditional non-human models have inherent limitations in replicating human-specific processes.
Recent advancements enable the recapitulation of key in vivo neurodevelopmental features in organoids.

Purpose of the Study:

To review the potential of cerebral organoids for modeling human brain development and evolution.
To discuss the progress and challenges in using organoids to reproduce human neurodevelopmental processes.

Main Methods:

Review of recent literature on cerebral organoid generation and application.
Analysis of organoid capabilities in recapitulating in vivo neurodevelopmental features.
Discussion of limitations in modeling specific human brain processes.

Main Results:

Organoids can model early to late stages of neurodevelopment.
Organoids have successfully recapitulated key features of in vivo neurodevelopment.
Effective use of organoids requires understanding their limitations.

Conclusions:

Cerebral organoids hold significant potential for studying human brain development and disease.
Further research is needed to address the limitations of organoids in accurately modeling specific neurodevelopmental processes.
Organoids are a valuable tool for advancing our understanding of the human brain.