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Protective potential of cerium oxide nanoparticles in diabetes mellitus

Wui Fang Chai1, Kim San Tang1

  • 1School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|March 27, 2021
PubMed
Abstract

Insights

Cerium oxide nanoparticles (CONPs) show promise for managing diabetes mellitus (DM) by reducing oxidative stress and disease complications. Further research supports CONPs as a potential therapeutic agent for diabetes treatment.

Area of Science:

  • Nanotechnology
  • Biomedical Science
  • Pharmacology

Background:

  • Diabetes mellitus (DM) is a metabolic disease linked to oxidative stress and high glucose levels.
  • Current antidiabetic drugs manage blood glucose but do not halt disease progression.
  • New therapeutic strategies are needed to address DM and its complications.

Purpose of the Study:

  • To critically evaluate the pharmacological and antidiabetic effects of cerium oxide nanoparticles (CONPs).
  • To assess the role of CONPs in mitigating diabetes mellitus and its associated complications in preclinical models.

Main Methods:

  • A literature search was performed on PubMed using keywords related to cerium oxide and diabetes.
  • Inclusion criteria focused on primary research investigating CONPs in DM and its complications.
  • The search covered literature from inception to December 2020.

Main Results:

  • 31 articles were included after screening 47 initial results.
  • Cerium oxide nanoparticles demonstrated the ability to attenuate DM-related parameters.
  • CONPs showed efficacy in various animal and cell culture models of diabetes and its complications.

Conclusions:

  • Cerium oxide nanoparticles exhibit potential as a therapeutic option for managing diabetes mellitus.
  • CONPs may help in treating complications arising from diabetes.
  • This review highlights the promising role of nanotechnology in diabetes management.
Keywords:
AntioxidantsCerium oxideDiabetes complicationsDiabetes mellitusNanoparticlesOxidative stress

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