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Reducing anticholinergic medication exposure among older adults using consumer technology: Protocol for a randomized
Ephrem Abebe1, Noll L Campbell2, Daniel O Clark3
1Department of Pharmacy Practice, Purdue University College of Pharmacy, West Lafayette, IN, USA; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Research in Social & Administrative Pharmacy : RSAP
|March 28, 2021
Summary
This study tested a mobile app to help older adults reduce exposure to anticholinergic medications, which can harm cognition. The app aims to empower patients in deprescribing potentially risky drugs.
Area of Science:
- Gerontology
- Clinical Pharmacology
- Digital Health
Background:
- Anticholinergic medications pose risks to cognitive function in older adults.
- Current deprescribing interventions primarily target healthcare professionals with limited success.
- Patient empowerment through technology offers a novel approach to medication safety.
Purpose of the Study:
- To evaluate the effectiveness of a patient-facing mobile application (Brain Safe app) in reducing anticholinergic exposure.
- To compare the Brain Safe app against an attention control medication list app.
- To assess the impact on cognitive function and quality of life in older adults.
Main Methods:
- A randomized clinical trial involving 700 community-dwelling older adults (≥60 years) using prescribed strong anticholinergics.
- Participants were randomized to receive either the Brain Safe app or a control app.
- Data collection included anticholinergic exposure (primary outcome), cognitive function, and quality of life over 12 months.
Main Results:
- The study is ongoing; results are not yet available.
- The primary outcome is anticholinergic exposure measured by total standard daily dose (TSDD).
- Secondary outcomes include changes in cognitive function and health-related quality of life.
Conclusions:
- Consumer-facing digital interventions show promise for promoting medication deprescribing in older adults.
- Mobile applications can be a scalable tool to enhance medication safety initiatives.
- Empowering patients with technology may improve adherence to deprescribing recommendations.
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