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Related Experiment Videos

Alveolar soft-part sarcoma.

J G Batsakis1

  • 1Division of Pathology, M.D. Anderson Hospital, Texas Medical Center, Houston 77030.

The Annals of Otology, Rhinology, and Laryngology
|May 1, 1988
PubMed
Summary

Alveolar soft-part sarcomas often originate in the head, particularly the tongue and orbit. Their exact origin (histogenesis) is unknown, but they are known for recurrence, metastasis, and prolonged lethality.

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Alveolar soft-part sarcomas (ASPS) are rare soft tissue neoplasms.
  • Approximately 25% of ASPS cases originate in the head and neck region.
  • The tongue and orbit are common primary sites for head and neck ASPS.

Purpose of the Study:

  • To review the clinicopathologic features of ASPS.
  • To discuss the characteristic light and electron microscopic findings.
  • To highlight the known biologic behavior of ASPS.

Main Methods:

  • Review of existing literature on ASPS.
  • Analysis of characteristic histopathologic and ultrastructural features.
  • Discussion of clinical presentation and outcomes.

Main Results:

  • ASPS exhibit distinct light and electron microscopic features.
  • Head and neck ASPS, particularly those in the tongue and orbit, are common.
  • The histogenesis of ASPS remains undetermined.

Conclusions:

  • ASPS are characterized by aggressive behavior, including frequent recurrences and early metastasis.
  • Despite characteristic morphology, the precise origin of ASPS is not fully understood.
  • The prolonged lethality associated with ASPS necessitates further research into their biology.

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