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Hypercoagulability Testing and Hypercoagulable Disorders in Young Central Retinal Vein Occlusion Patients
Zujaja Tauqeer1, Peter Bracha2, Brendan McGeehan3
1Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Ophthalmology. Retina
|March 28, 2021
Summary
In young patients with central retinal vein occlusion (CRVO), 11.5% developed hypercoagulable states. Testing for hypercoagulability was infrequent at 38.1%, yet significantly increased diagnosis rates.
Area of Science:
- Ophthalmology
- Hematology
- Vascular Medicine
Background:
- Central retinal vein occlusion (CRVO) in patients under 50 is uncommon.
- Identifying underlying causes like hypercoagulable states is crucial for management and prevention.
- Risk factors for atherosclerosis are often evaluated, but hypercoagulability testing frequency is unclear.
Purpose of the Study:
- To determine the frequency of hypercoagulability testing in young CRVO patients.
- To ascertain the prevalence of diagnosed hypercoagulable states within one year of CRVO.
- To analyze the association between testing and diagnosis rates.
Main Methods:
- Retrospective cohort study using a national insurance claims database.
- Included patients under 50 with newly diagnosed CRVO.
- Analyzed claims for hypercoagulability workup within 90 days and diagnoses within one year.
Main Results:
- 11.5% of young CRVO patients were diagnosed with a hypercoagulable state within a year.
- Only 38.1% of patients underwent hypercoagulability testing within 90 days of CRVO.
- Testing was associated with a higher diagnosis rate (20.7% vs. 5.9%, P < 0.001).
Conclusions:
- A significant proportion of young CRVO patients have hypercoagulable states.
- Current testing rates are low, despite its diagnostic utility.
- Further research is needed to evaluate standardized hypercoagulability screening in this population.
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