Determination and occurrence of bisphenol A and thirteen structural analogs in soil

Bisphenol A is a phenolic plasticizer used in the production of various plastic products. Its endocrine-disrupting effects on ecological and human health lead to replacement with its structural analogs. The occurrence of these analogs in the soil environment, which is an important sink for bisphenols, has been rarely reported. In this study, a robust method was developed to determine bisphenol A and 13 analogs in soil using accelerated solvent extraction combined with in-line purification for fast and efficient extraction and ultra-performance liquid chromatography-tandem mass spectrometry for simultaneous and accurate quantification. The method detection limits of 14 bisphenols were between 0.01 and 0.39 ng g^-1, and the recoveries were in the range of 80%-120%. The developed method was applied to 29 agricultural and urban soil samples from 21 provinces in China, and 12 bisphenols were detected. Among them, the contents of bisphenol A, F, and P were up to 166.0, 212.9, and 78.2 ng g^-1 dry weight, respectively. The maximum concentration of bisphenol P was at least ten times higher than literature values in food and other environmental matrices. The results of this study showed that "hot spots" existed for bisphenol pollution in soil and that further investigations were necessary to avoid regrettable substitutions.