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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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Hypercalcemia and renal insufficiency – where can we start?
Nóra Garam1, András Tislér1, Ákos Pethő1
11 Semmelweis Egyetem, Általános Orvostudományi Kar, Belgyógyászati és Onkológiai Klinika, Budapest, Korányi Sándor u. 2/a, 1083.
Orvosi Hetilap
|March 28, 2021
Summary
This case study highlights a rare instance of Boeck sarcoidosis presenting as extrapulmonary disease. The patient experienced hypercalcemia and renal insufficiency, emphasizing the need to consider sarcoidosis in differential diagnoses.
Area of Science:
- Nephrology
- Pulmonology
- Rheumatology
- Endocrinology
Background:
- Boeck sarcoidosis is a multisystem inflammatory disease.
- Extrapulmonary manifestations, particularly without lung involvement, are uncommon.
- Hypercalcemia and renal insufficiency are potential complications.
Observation:
- A 63-year-old male presented with fatigue, weight loss, hypercalcemia, and renal insufficiency.
- Radiographic findings included skull and sacral bone lesions and splenomegaly.
- Initial differential diagnoses included multiple myeloma, but it was not confirmed.
Findings:
- Bone marrow and renal biopsies confirmed Boeck sarcoidosis.
- Elevated serum angiotensin-converting enzyme (ACE) levels supported the diagnosis.
- The patient showed significant symptom improvement with oral corticosteroid therapy.
Implications:
- This case underscores the importance of considering Boeck sarcoidosis in patients with unexplained hypercalcemia and renal failure.
- Early diagnosis and treatment of extrapulmonary sarcoidosis are crucial for patient outcomes.
- Further research into rare presentations of sarcoidosis can improve diagnostic accuracy.
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