A Journey through the Early Evidence Linking Hydration to Metabolic Health
Tiphaine Vanhaecke1, Erica T Perrier1, Olle Melander2,3
1Health, Hydration and Nutrition Science Department, Danone Research, Palaiseau, France.
Annals of Nutrition & Metabolism
|March 28, 2021
Summary
Adequate water intake and hydration may independently influence metabolic health. Studies link higher arginine vasopressin (AVP) to increased risk of type 2 diabetes and metabolic syndrome, suggesting hydration
Area of Science:
- Endocrinology
- Metabolic Health
- Hydration Physiology
Background:
- Metabolic dysfunction is linked to body water balance challenges and elevated arginine vasopressin (AVP).
- Altering fluid balance in individuals with metabolic issues can exacerbate their condition, indicating hydration's role in glycemic control.
Purpose of the Study:
- To explore the link between water intake, hydration status, and metabolic health.
- To investigate the role of the hydration-vasopressin axis in metabolic disease pathophysiology.
Main Methods:
- Review of early experimental works and recent observational/interventional studies.
- Analysis of associations between AVP (or copeptin) levels and metabolic disease risk factors.
- Examination of preclinical data and short-term water supplementation trials.
Main Results:
- Higher AVP levels correlate with increased risk for type 2 diabetes and metabolic syndrome, independent of known risk factors.
- Low habitual fluid intake is associated with higher circulating AVP, which can be reduced by increasing water intake.
- Short-term water supplementation may decrease fasting glucose and glucagon in low drinkers with high copeptin.
Conclusions:
- The hydration-vasopressin axis is implicated in metabolic disease development.
- Water supplementation shows promise as a strategy to reduce metabolic disease incidence.
- An ongoing randomized trial will further assess the long-term effects of water supplementation on cardiometabolic risk factors.
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