Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

308
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
308
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

244
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
244
Long-term Depression01:03

Long-term Depression

2.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.7K
Long-term Depression01:05

Long-term Depression

32.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.3K
Depression: Overview01:18

Depression: Overview

534
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
534
Bipolar Disorder01:30

Bipolar Disorder

273
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
273

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient Deep Learning Models for Predicting Individualized Task Activation From Resting-State Functional Connectivity.

Human brain mapping·2026
Same author

Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early Psychosis.

bioRxiv : the preprint server for biology·2026
Same author

Predicting Substance Use and Psychotic-Like Experiences in Adolescents.

medRxiv : the preprint server for health sciences·2026
Same author

Refining RDoC Using Individual-Level Task fMRI Factor Models Reveals Reproducible and Clinically Relevant Brain-Wide Motifs.

bioRxiv : the preprint server for biology·2026
Same author

Convergent and divergent brain-cognition development in early adolescence.

Nature communications·2026
Same author

Bullying, State Policy, and Mental Health Symptoms in Gender-Diverse Youths.

JAMA network open·2026

Related Experiment Video

Updated: Nov 11, 2025

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil
09:30

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

Published on: October 4, 2016

22.6K

Whole-Brain Functional Dynamics Track Depressive Symptom Severity.

Zachary T Goodman1, Sierra A Bainter1, Salome Kornfeld2

  • 1Department of Psychology, University of Miami, Coral Gables, FL, USA.

Cerebral Cortex (New York, N.Y. : 1991)
|March 28, 2021
PubMed
Summary
This summary is machine-generated.

Depression is linked to altered brain network activity. This study found that higher depressive symptoms correlate with increased default mode network activity and decreased cognitive control network activity in adults.

Keywords:
brain network dynamicscoactivation pattern analysisdepressive symptomsmedial frontoparietal networkresting state fMRI

More Related Videos

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.8K
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.5K

Related Experiment Videos

Last Updated: Nov 11, 2025

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil
09:30

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

Published on: October 4, 2016

22.6K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.8K
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.5K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Depressive symptoms affect 20% of the population, linked to brain network dysfunction.
  • The dynamic relationship between brain function and depressive symptoms is understudied.

Purpose of the Study:

  • Examine functional brain dynamics in relation to subclinical and mild depressive symptoms.
  • Investigate these dynamics in a large community sample of adults.

Main Methods:

  • Utilized resting-state functional MRI data from the Enhanced Nathan Kline Institute-Rockland Sample (445 adults, 18-65 years).
  • Employed coactivation pattern analysis to assess brain states and depressive symptoms.

Main Results:

  • Elevated depressive symptoms correlated with increased default mode network (DMN) frequency and duration.
  • Higher depressive symptom severity was associated with reduced activity in a cognitive control network.

Conclusions:

  • Dynamic functional brain activity patterns are associated with depressive symptoms.
  • Findings highlight the role of DMN and cognitive control networks in depression.