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Updated: Nov 11, 2025

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
[Neuroimaging for the diagnosis of dementia.]
L R Ahmadeeva1, D E Baikov1, R R Valitova2
1Bashkir State Medical University, 3 Lenina str., Ufa 450008, Russian Federation,
Abstract:
Development of laboratory diagnosis and neuroimaging revealed some biomarkers for in vivo diagnosis of the most common forms of dementia (Alzheimer's disease, Lewy body dementia and vascular dementia) for their differential diagnosis. Structural changes found using magnetic resonance imaging (MRI) are significant for the prognosis of the cognitive decline. Cerebral microbleeds are an available adjuvant diagnostic marker, which increases the diagnostic value of leukoaraiosis that suggests the development of cerebral amyloid angiopathy or hypertensive microangiopathy, especially in cases of mixed causes of dementia and severe cognitive deficits. We describe our own clinical case and the results of digital voxel hippocampometry as an example of effective usage of neuroimaging for the differential diagnosis of dementia.
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