Related Experiment Video
Updated: Nov 11, 2025
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
Published on: February 27, 2019
The role of peptide-based therapeutics in oncotherapy
Selin Seda Timur1, R Neslihan Gürsoy1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Abstract:
Cancer is the second leading cause of death worldwide, and the search for specialised therapy options has been a challenge for decades. The emergence of active targeted therapies provides the opportunity to treat cancerous tissues without harming healthy ones due to peculiar physiological changes. Herein, peptides and peptide analogs have been gaining a lot of attention over the last decade, especially for the on-site delivery of therapeutics to target tissues in order to achieve efficient and reliable cancer treatment. Combining peptides with highly efficient drug delivery platforms could potentially eliminate off-target adverse effects encountered during active targeting of conventional chemotherapeutics. Small size, ease of production and characterisation, low immunogenicity and satisfactory binding affinity of peptides offer some advantages over other complex targeting moiety, no wonder the market of peptide-based drugs continues to expand expeditiously. It is estimated that the global peptide drug market will be worth around USD 48.04 billion by 2025, with a compound annual growth rate of 9.4%. In this review, the current state of art of peptide-based therapeutics with special interest on tumour targeting peptides has been discussed. Moreover, various active targeting strategies such as the use functionalised peptides or peptide analogs are also elaborated.
Insights
Peptide-based therapeutics offer a promising approach for targeted cancer treatment, minimizing harm to healthy tissues. This review explores tumor-targeting peptides and their application in advanced drug delivery systems.
Area of Science:
- Oncology
- Pharmacology
- Biotechnology
Background:
- Cancer remains a leading global cause of death, necessitating innovative therapeutic strategies.
- Active targeted therapies exploit physiological differences in cancerous tissues for selective treatment.
- Peptide-based therapeutics have emerged as a significant area of research for cancer treatment.
Purpose of the Study:
- To review the current advancements in peptide-based therapeutics for cancer.
- To highlight the role of tumor-targeting peptides in drug delivery.
- To discuss active targeting strategies using peptides and peptide analogs.
Main Methods:
- Review of current literature on peptide-based cancer therapeutics.
- Analysis of active targeting strategies involving functionalized peptides and peptide analogs.
- Discussion of the advantages of peptides in drug delivery platforms.
Main Results:
- Peptides offer advantages such as small size, ease of production, low immunogenicity, and good binding affinity.
- Combining peptides with drug delivery platforms can reduce off-target effects of chemotherapeutics.
- The global peptide drug market is experiencing rapid expansion, projected to reach USD 48.04 billion by 2025.
Conclusions:
- Peptide-based therapeutics represent a viable and expanding field for effective and targeted cancer treatment.
- Functionalized peptides and peptide analogs are key components in advanced cancer therapy strategies.
- Further development in this area holds significant potential for improving patient outcomes in oncology.
More Related Videos
08:48Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
10:18Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
Published on: July 7, 2023
Related Concept Videos
01:27Tumor Immunotherapy
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:30Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
02:38Mitogens and the Cell Cycle