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Updated: Nov 11, 2025
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Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
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Lymphocytic thrombophilic arteritis with lower-limb ulcers
Jessica Shen Tsy Wu Kim1, Valeria Romero Godofredo1, Milvia Maria Simões E Silva Enokihara2
1Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Anais Brasileiros De Dermatologia
|March 29, 2021
Summary
Lymphocytic thrombophilic arteritis, a rare vasculitis, can present as skin ulcers. Treatment with azathioprine showed a positive clinical response in a recent case study.
Area of Science:
- Dermatology
- Pathology
- Rheumatology
Background:
- Lymphocytic thrombophilic arteritis (LTA) is a recently identified vasculitic condition.
- It is characterized by lymphocytic inflammation of arterioles at the dermo-hypodermic junction.
Observation:
- A 49-year-old female presented with achromic maculae and a leg ulcer.
- Histopathology revealed lymphocytic vasculitis with fibrin deposition and a vascular fibrin ring.
Findings:
- Biopsy confirmed lymphocytic infiltrate and vascular wall destruction.
- Masson's trichrome staining highlighted fibrin ring and muscle layer damage.
Implications:
- This case suggests skin ulceration may be a clinical manifestation of LTA.
- Azathioprine demonstrated efficacy, indicating a potential treatment option for this condition.
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