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Optimization of psoriasis mouse models.

Christina Karamani1, Ivi Theodosia Antoniadou1, Aikaterini Dimou1

  • 1National and Kapodistrian University of Athens, School of Health Sciences, Department of Pharmacy, Section of Pharmaceutical Technology, Panepistimiopolis, 15784 Athens, Greece.

Journal of Pharmacological and Toxicological Methods
|March 29, 2021
PubMed
Summary
This summary is machine-generated.

The BALB/c mouse strain with topical imiquimod (IMQ) plus acetic acid (AcOH) treatment provides an optimal psoriasis-like model. This combination effectively induced a psoriasis phenotype in BALB/c mice, outperforming other strains and treatments.

Keywords:
Acetic acidBehaviourImiquimodModelMousePsoriasis

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Area of Science:

  • Immunology
  • Dermatology
  • Pharmacology

Background:

  • Psoriasis is a chronic autoimmune inflammatory disease requiring effective preclinical models.
  • The imiquimod (IMQ)-induced psoriasis-like mouse model is widely used but requires optimization.
  • Equivalency across mouse strains and suitability of hairless mice for this model are unclear.

Purpose of the Study:

  • To compare common and hairless mouse strains for their suitability in an imiquimod-induced psoriasis-like model.
  • To evaluate the efficacy of different imiquimod (IMQ) and acetic acid (AcOH) treatment regimens.
  • To optimize the imiquimod-induced psoriasis-like mouse model for pre-clinical drug testing.

Main Methods:

  • Comparative analysis of BALB/c, C57BL/6J, ApoE, and ApoE/SKH-hr2 (hairless) mouse strains.
  • Application of imiquimod (IMQ) alone, IMQ + acetic acid (AcOH) topically, and IMQ + AcOH systemically.
  • Assessment via clinical, histopathological, biophysical, and locomotor activity evaluations.

Main Results:

  • BALB/c mice treated with IMQ + AcOH topically exhibited an optimal psoriasis-like phenotype.
  • C57BL/6J mice showed a moderate phenotype, while ApoE mice displayed a mild phenotype.
  • ApoE/SKH-hr2 mice lacked Munro's abscess, questioning their psoriasis-like phenotype acquisition.
  • Locomotor activity in BALB/c mice decreased with all IMQ + AcOH treatments.

Conclusions:

  • The BALB/c mouse strain is optimal for imiquimod-induced psoriasis-like models using topical IMQ + AcOH.
  • This optimized model facilitates pre-clinical drug evaluation and mechanistic studies for psoriasis.
  • The findings aid in selecting appropriate mouse strains and treatment protocols for psoriasis research.