Related Experiment Video

Updated: Nov 11, 2025

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
11:18

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

16.3K

An Open Access Database of Licensed Cancer Drugs

Pan Pantziarka1,2, Rica Capistrano I1, Arno De Potter3

  • 1The Anticancer Fund, Brussels, Belgium.

Frontiers in Pharmacology
|March 29, 2021
PubMed

Insights

A comprehensive, open-access database of approved anticancer drugs was created by combining and cleansing data from multiple sources. This resource aids researchers in oncology drug discovery and repurposing efforts.

Area of Science:

  • Oncology
  • Pharmacology
  • Bioinformatics

Background:

  • Existing anticancer drug information is fragmented across various sources.
  • Current databases often include non-antineoplastic drugs, complicating research.
  • A unified, specialized list of antineoplastic agents is lacking.

Purpose of the Study:

  • To develop a methodology for creating a comprehensive, open-access database of approved anticancer drugs.
  • To curate a list of drugs licensed specifically for antineoplastic purposes.
  • To provide a valuable resource for cancer research, including drug repurposing.

Main Methods:

  • Data aggregation from multiple sources (regulatory authorities, national formularies, scientific agencies).
  • Data cleansing and validation to ensure accuracy and relevance.
  • Development of a methodology for systematic data integration.

Main Results:

  • Creation of an open-access database of approved anticancer drugs.
  • The database specifically lists drugs for therapeutic antineoplastic use.
  • The database is accessible at http://www.redo-project.org/cancer-drugs-db/.

Conclusions:

  • The developed methodology successfully created a specialized anticancer drug database.
  • This open-access resource facilitates further research in oncology.
  • The database supports initiatives like text mining for drug repurposing.
Keywords:
antineoplastic drugsdatabasedrug licensingdrug repurposinglicensed drugslist of cancer drugs

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.2K
Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs10:38

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs

Published on: December 16, 2022

2.4K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.5K
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
51.6K
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
994
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.1K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
508