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Related Concept Videos

Pulse rhythm01:30

Pulse rhythm

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Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
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Related Experiment Video

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High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
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Automatic Extraction of Recurrent Patterns of High Dominant Frequency Mapping During Human Persistent Atrial

Xin Li1,2, Gavin S Chu1, Tiago P Almeida1,2

  • 1Department of Cardiovascular Science, University of Leicester, Leicester, United Kingdom.

Frontiers in Physiology
|March 29, 2021
PubMed
Summary

Researchers developed a tool to identify recurring dominant frequency (DF) patterns in persistent atrial fibrillation (persAF). These dominant patterns (DPs) showed more organized rhythms, suggesting potential targets for catheter ablation therapy.

Keywords:
atrial electrogramsatrial fibrillationcatheter ablation – atrial fibrillationdominant frequency analysesnon-contact mappingpattern recognitionrecurrent patternsspatiotemporal patterns

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Signal Processing

Background:

  • Identifying ablation targets for persistent atrial fibrillation (persAF) remains challenging.
  • Dominant frequency (DF) reflects local atrial activation, with highest DF (HDF) potentially driving persAF.
  • The spatiotemporal dynamics of DF in persAF are not fully understood.

Purpose of the Study:

  • To develop an automated tool for detecting recurrent HDF spatial patterns in persAF patients.
  • To analyze the characteristics and recurrence of these dominant patterns (DPs).

Main Methods:

  • Non-contact mapping of the left atrium in 10 persAF patients undergoing HDF ablation.
  • Collected 2,048 virtual electrograms (vEGMs) and calculated DF and organization index (OI).
  • Utilized an automated pattern recognition algorithm to identify recurring HDF spatial patterns (DPs).

Main Results:

  • DPs were identified in all patients.
  • Recurrence intervals of DPs decreased post-ablation in patients with persAF.
  • DPs exhibited more stable DF and higher OI compared to non-DP regions.
  • Septum and left upper pulmonary vein showed the highest proportion of HDF regions.

Conclusions:

  • Multiple recurrent HDF patterns exist in persAF, offering dynamic insights into the arrhythmia.
  • The developed method effectively quantifies HDF spatiotemporal repetition.
  • Targeting regions with recurring DPs may improve catheter ablation outcomes in persAF.