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Heart Enhancers: Development and Disease Control at a Distance
Xuefei Yuan1,2, Ian C Scott2,3, Michael D Wilson1,3
1Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Frontiers in Genetics
|March 29, 2021
Summary
Understanding heart enhancers is crucial for cardiac development and disease. Advances in functional genomics and developmental biology have enabled genome-wide annotation of these key genetic elements and their targets.
Area of Science:
- Cardiovascular Biology
- Developmental Biology
- Genomics
Background:
- Enhancers are critical regulatory DNA elements controlling gene expression.
- Lineage-determining transcription factors and signaling pathways govern enhancer activity.
- Cardiac development, homeostasis, and disease are intricately linked to spatiotemporal gene expression.
Purpose of the Study:
- To review the advancements in identifying and studying heart enhancers.
- To highlight the role of heart enhancers in cardiac development and disease.
- To discuss the impact of functional genomic technologies on enhancer research.
Main Methods:
- Review of early studies on vertebrate heart enhancers.
- Integration of functional genomic technologies for genome-wide annotation.
- Application of developmental biology tools for enhancer discovery and testing.
Main Results:
- Unprecedented genome-wide annotation of heart enhancers and their target genes has been achieved.
- Studying heart enhancers across metazoan species provides insights into conserved mechanisms.
- Understanding enhancer function is key to deciphering cardiac development and disease etiology.
Conclusions:
- Functional genomics and developmental biology have revolutionized heart enhancer research.
- Heart enhancers are vital for understanding cardiac development and disease.
- Future research on enhancers will continue to advance cardiovascular science.
Keywords:
cardiac gene expressioncomparative genomicsenhancerepigenomics and epigeneticsgene regulationtranscription factor (TF)More Related Videos
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