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Catalase immunoexpression in colorectal lesions
Adam Piecuch1, Józef Kurek2, Marek Kucharzewski3
1Department of Histology and Cell Pathology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
Przeglad Gastroenterologiczny
|March 29, 2021
Summary
Catalase (CAT) expression increases in colorectal adenomas but decreases in adenocarcinomas, suggesting a role in colorectal cancer development. This study investigated CAT protein levels in patient samples.
Area of Science:
- Oncology
- Gastroenterology
- Biochemistry
Background:
- The colon is exposed to reactive oxygen species (ROS), necessitating antioxidant defenses.
- Decreased levels of antioxidant enzymes, particularly catalase (CAT), are noted in cancer tissues.
- Understanding CAT's role in colorectal neoplasia is crucial for cancer research.
Purpose of the Study:
- To evaluate the immunohistochemical expression of catalase (CAT) protein in colorectal adenoma and adenocarcinoma.
- To correlate CAT expression with clinicopathological features of colorectal tumors.
Main Methods:
- Analysis of 122 colorectal cancer and 120 adenoma patient specimens.
- Immunohistochemical staining using a rabbit polyclonal anti-CAT antibody.
- Assessment of CAT protein expression in tissue sections.
Main Results:
- In adenomas, strong CAT immunoexpression was observed in infiltrating mononuclear cells and associated with high-grade dysplasia.
- In adenocarcinomas, high CAT immunoexpression correlated significantly with tumor histological grade and depth of invasion.
- A significant association was found between CAT expression and grade of dysplasia (p=0.037) and tumor progression (p=0.001).
Conclusions:
- Catalase expression is elevated in the adenoma stage of colorectal cancer development.
- A decrease in catalase expression is observed in the adenocarcinoma stage.
- These findings suggest a dynamic role for CAT in the progression of colorectal neoplasia.
